Program

Scheduled Abstracts by Division
Biological and Medicinal Chemistry
Monday AM
BM1
202D
Bionanomaterials
Organizer(s) - John Honek, Hanadi Sleiman
Chair(s) - John Honek, Hanadi Sleiman, Jan Rainey
08:00
Externally Actuated Injectable, Anisotropic Cellulose Nanocrystal Nanocomposite Hydrogels De France KJ, Yager KG, Chan KJW, Cranston ED, Hoare T
08:20
Gold-coated Polystyrene Beads as a Platform for the Multiplex Detection of Short Oligonucleotides Fakih H, Abou Shaheen S, $*Karam P
08:40
Barriers to Delivering Nanomaterials to Tumour Tissues In Vivo $*Chan WCW
09:20
Second Generation Molecular Sieving Coatings for the Improved Treatment of Leukemia Using Asparaginase Congdon TR, *Gauthier MA
09:40
Highly-ordered Porphyrin J-Aggregate Assemblies in Lipid Membranes for Theranostic Nanomedicine Charron DM, Liu R, $*Zheng G
10:00
 
Coffee Break
10:20
Understanding the Kinetics and Dynamics of DNA Nanotubes: A Single Molecule Study Platnich CM, Hariri AA, Rahbani JF, Sleiman HF, Cosa G
10:40
Exploring the Interactions between Biomolecules and External Energy Sources for Novel DNA Assembly Strategies *Greschner AA, Ropagnol X, Kort M, Zuberi N, Perreault J, Razzari L, Ozaki T, $Gauthier M
11:00
Amphiphilic Cyclodextrin-based Glycodendrimers as a Tool to Study Biological Interactions Zhang P, Wang A, Sadowska J, Matinez de la Pena C, Amstrong G, Bundle DR, $*Ling C-C
11:20
 
End of Session
BM3
104A
Chemical Biology and Imaging - joint with OR
Organizer(s) - Peter Brown, Len Luyt, Mark Nitz, Chris Phenix, Santha Santhakumar
Chair(s) - Peter J Brown
08:00
A Chemical Proteomics Approach to Studying the Metabolism and Mode of Action of Insecticides Adeniji OA, Woscholski R, Cass T, Daniels M, Jeanguenat A, $*Spivey AC
08:20
Epigenetic Chemical Probes for Target Validation Brown PJ
09:00
Pharmacological Probes and the Role of Autophagy in Health and Disease $*Young RN
09:40
Structure Activity Relationship of Caffeic Acid Phenethyl Ester Analogs as New 5-lipoxygenase Inhibitors $*Touaibia M
10:00
 
Coffee Break
10:20
Development of Molecular Probes for the Study of the Zinc-finger Ubiquitin Domain in HDAC6 Franzoni I, Freitas R, Harding R, Brown P, Arrowsmith C, Schapira M, Santhakumar V, Lautens M, $*Santhakumar V
10:40
Discovery & Optimization of First-in-Class p300 Histone Acetyl Transferase Inhibitors *Mastracchio A, $Mchaelides M
11:20
 
End of Session
BM4
201E
Bio-inorganic Chemistry - joint with IN
Organizer(s) - Bernie Kraatz, Deborah Zamble
Chair(s) - Deborah Zamble
08:00
Computational Electronic Structure of Iron and Manganese Centers in ROS-scavaging Enzymes Rodriguez JH
08:20
Probing the Active Site Environment of Anthrax Lethal Factor with Transition Metals Young CJ, Lo SY, *Siemann S
08:40
The Bridge between Acid Acclimation and Nickel Homeostasis in Helicobacter pylori through the NikR Transcription Factor Jones MD, $Zamble DB
09:00
The Repair of Iron Center Protein YtfE is an Nitric Oxide Reductase *Bohle DS, Lo F-C, Liaw W-F
09:20
Multicopper Metallo-oxidases in Managing Iron and Copper in the Neurovascular Unit $*Kosman DJ
10:00
 
Coffee Break
10:20
Dissecting Function and Regulation of Iron and Copper Transporters in Staphylococcus aureus $*Heinrichs DE
10:40
Monothiol Grxs and BolA Proteins: Intracellular Fe-S Cluster Chaperones $*Outten CE
11:20
 
End of Session
BM5
201C
Medicinal Chemistry - joint with OR
Organizer(s) - Donald Weaver
Chair(s) - Donald Weaver
08:20
Natural Products Biosynthesis and Probing Enzymatic Phosphoryl Transfer $*Jakeman DL
09:00
Developing Inhibitors of Aminoglycoside Resistance Enzymes to Rescue Antibiotic Activity Leung MRMLC, Leckett KC, Li X, Chaudhry A, $Capretta A
09:20
Aminoglycoside-based Adjuvants: Rescuing Antibiotics from Resistance in Gram-negative Bacteria $*Schweizer F
10:00
 
Coffee Break
10:20
Microparticle Formation in Red Blood Cells Stored with Ice Recrystallization Inhibitors Meyer JE, $*Ben RN, Turner TR, Acker JP, Burger D
10:40
Design of Bone Targeting Prodrug Conjugates for Treatment of Osteoporosis and Other Bone-related Diseases $*Young RN, Chen G, Thévenin M, Xie H
11:20
 
End of Session
Monday PM
BM1
202D
Bionanomaterials
Organizer(s) - John Honek, Hanadi Sleiman
Chair(s) - Hanadi Sleiman, Jan Rainey
13:40
Nanomaterials from DNA Hybrids and Supercharged Polypeptides for Biomedicine Herrmann A
14:20
Nanosafety and Toxicity Assessment of Nanomaterial by Using Sponteous Beating Cardiomyocytes and AFM $*Zou S
14:40
UV Photopolymerizable Starch Nanoparticle (SNP) Network Hydrogels for Biomedical Applications Majcher MJ, McInnis CL, Smeets NMB, $Hoare TR
15:00
Gadolinium-based Nanoparticles as Vascular Contrast Agents for Micro-computed Tomography *Cruje C, Holdsworth DW, Drangova M, $Gillies ER
15:20
Synthesis of Covalently Linked Photoluminescent Magnetic Magnetite Nanoparticle-silicon Nanocrystal Hybrids for Biological Imaging Javadi M, Ortega VA, Aghajamali M, Islam MA, Washington J, Goss GG, *Veinot JGC
15:40
 
Coffee Break
16:00
Spider Wrapping Silk Protein Engineering and Fibre Spinning Xu L, Weatherbee-Martin N, Tremblay M-L, Sarker M, Orrell KE, Liu X-Q, *Rainey JK
16:40
Quantifying the Biological Fate of Nanosilver $*Kennedy DC
17:00
Synthesis and Characterization of Tailored ApoE Porphyrin-lipid Nanoparticles for Glioblastoma-targeted Imaging and Therapy *Rajora MR, Ding L, Valic M, Overchuk M, Chen J, $Zheng G
17:20
Genetically Encoded Nanoparticles for Delivery of Chemotheraputics $*Chilkoti A
18:00
 
End of Session
BM3
104A
Chemical Biology and Imaging - joint with OR
Organizer(s) - Peter Brown, Len Luyt, Mark Nitz, Chris Phenix, Santha Santhakumar
Chair(s) - Santha Santhakumar
13:40
DB2-082: A Selective Chemical Probe for the Key Autophagy Enzyme ATG4B Clark PGK, Kovacic S, Bosc D, Chen G, $*Young RN
14:00
Targeted Covalent Inhibitors of the STAT Proteins $*Gunning PT
14:40
Development of Chemical Tools for Monitoring and Inhibiting O-GlcNAc Transferase Activity Alteen MG, Eskandari R, Tan HY, $*Vocadlo DJ
15:00
Generation of Chemical Probes for Historically Understudied Kinases Zuercher WJ
15:40
 
Coffee Break
16:00
Small-molecule Inhibitors of PD1/PDL1 Excel In Vitro, but What about In-cell? Hanley RP, Walker K, Horvath SW, Messmer D, Thompson M, Powell D, Carr MD, Hof F, $*Wulff JE
16:20
Using Chemical Proteomics to Study Pyridoxal Phosphate Dependent Enzymes in Cells Hoegl A, Nodwell M, Schneider S, $Sieber SA
16:40
Preparation and Application of Carbon-13 Isotopomers of myo-Inositol Ramos-Figueroa J, Aamudalipalli H, Smith J, Jagdhane R, $*Palmer DRJ
17:00
Novel Uses of Phophinic Acid-based Inhibitors Liu Y, Soni A, *Tanner ME
17:20
Coupling Hemoglobins to Produce Blood Substitutes that Avoid Known Problems $*Kluger R, Singh S, Wang A, Dubinsky I
17:40
 
End of Session
BM4
201E
Bio-inorganic Chemistry - joint with IN
Organizer(s) - Bernie Kraatz, Deborah Zamble
Chair(s) - Bernie Kraatz
13:40
 
Clara Benson Award Lecture
13:40
Hemoglobin - A Conformationally Gated Nanobioreactor that Synergizes O2 and NO Binding to Match O2 Delivery with Metabolic Demand $*English AM, Shadrina MS, Peslherbe GH
14:20
Light-driven P450 Biocatalysts for Selective C-H Functionalization $*Cheruzel L
14:40
Sensitivity and Pharmacokinetics: Key Elements for the Design of Gd-free MRI Contrast Agents Based-on Mn-Porphyrin $*Zhang X-A
15:00
Insights into the Catalytic Mechanism of Arsenite Oxidase $*George GN, Warelow TP, Pushie MJ, Cotelesage JJH, Santini JM
15:20
The Bloodstream as a Critical Site to Gain Insight into the Origin of Metal-related Diseases $*Gailer J, Gibson MA, Sarpong-Kumankomah S, Sagmeister P, North AE
15:40
 
Coffee Break
16:00
Interactions of Biomolecules and Bacteria with Titanium at the Mineral Microbe Frontier $*Valentine AM
16:40
Binding Constants for Copper and Zinc Binding to Metallothionein: Solving Very Complicated Problems Using ESI Mass Spectrometry $*Stillman M, Scheller J, Heinlein L, Hartwig A
17:00
Reflections on Guanine Quadruplexes $*Petitjean A
17:20
Synthesis, Characterisation and Quadruplex DNA Binding Properties of Benzophenone Schiff Base Complexes *Pham SQT, Davis K, Yu H, Willis AC, $Ralph SF
17:40
 
End of Session
BM5
201C
Medicinal Chemistry - joint with OR
Organizer(s) - Donald Weaver
Chair(s) - Donald Weaver
13:40
 
Bernard Belleau Award Lecture
13:40
Targeted Covalent Inhibition of Tissue Transglutaminase in Cancer Stem Cells $*Keillor JW
14:20
Design and Development of STAT SH2 Domain Inhibitors Tin G, Park J, Ball D, *Cumaraswamy A, De Araujo E, $Gunning P
14:40
Computationally-aided Design and Synthesis of Dual Covalent Inhibitors for the Treatment of Cancer Plescia J, De Cesco S, Mariaule G, $Moitessier N
15:00
The Development of Simple Molecules Displaying Anti-inflammatory, Anti-metastatic and Anticancer Activities $*Bérubé G, Cloutier S, Leclerc M-F, Hamelin-Morrissette J, Girouard J, Boulanger V, Ramla D, Belgorosky D, Eiján AM, Reyes-Moreno C
15:20
Computer-aided Design, Synthesis and Biological Evaluation of New Dual Covalent Inhibitors as Cancer Therapeutics Janmamode N, *De Cesco S, $Moitessier N
15:40
 
Coffee Break
16:00
Synthesis of Sialyl Lewisx Analogues for Treatment of Inflammatory Related Diseases *Belouin AV, Simard R, Gillard L, Calosso M, Beauregard J, Maharsy W, Prévost M, Nemer M, $Guindon Y
16:20
Highly Selective Imaging Agents for Human Glucocerebrosidase Activity in Lysosomes of Live Cells Enables Development of a High Throughput Screening for Glucocerebrosidase Modulators $*Vocadlo DJ, Gros C, Deen M, Shan X, Shen DL, Yadav AK
16:40
Discovery of Small Molecule Dual Inhibitors of Both Ab and Tau Oligomerization for the treatment of AD $*Reed MA
17:00
Quinazoline Scaffolds as Pharmacological Tools to Study Amyloid Aggregation $*Nekkar Rao P, Mohamed T, Shakeri A
17:20
Does Substitution of BMAA for Serine Alter the Conformational Dynamics of the Amyloid Beta Peptide of Alzheimer's Disease? Molecular Dynamics Simulations $*Rauk A
17:40
 
End of Session
Tuesday AM
BM2
201C
Proteins
Organizer(s) - Jumi Shin, Drew Woolley
Chair(s) - Jumi Shin
08:00
Activity-based PIK Probes Detect Protein-protein Interactions Desrochers GF, Cornacchia C, McKay C, $*Pezacki JP
08:20
Probing the Triggers for Conformational Change in the MinE Bacterial Cell Division Regulator Ayed SH, Cloutier A, McLeod L, Wu J, $*Goto NK
08:40
Using Site-specific Labelling Strategies to Probe the Early Events of Protein Misfolding Pathways Kumita JR
09:20
Intrinsic Disorder in Proteins: Curse or Blessing? $*Gradinaru CC
10:00
 
Coffee Break
10:20
Structure and Function of the Long Antiparallel Coiled-coil Domains from Bacterial Condensins $*Oakley MG, Waldman VM, Li Y, Weitzel CS
11:00
Solid-state NMR Provides Evidence for Small-amplitude Slow Domain Motions in a Multi-spanning Transmembrane a-helical Protein Good DB, Pham C, Jagas J, Lewandowski JR, $*Ladizhansky V
11:20
Interaction of Apolipoprotein E with Amyloid-beta in the Presence of Epigallocatechin Gallate and its Derivatives Ganesh HVS, $*Kerman K
11:40
Role of Antibodies on Tau Phosphorylation and Microtubule Binding $*Martic S
12:00
 
End of Session
BM3
104A
Chemical Biology and Imaging - joint with OR
Organizer(s) - Peter Brown, Len Luyt, Mark Nitz, Chris Phenix, Santha Santhakumar
Chair(s) - Chris Phenix, Len Luyt
08:00
Using a Single Quad Mass Spectrometer in a Radiochemistry Lab $*Collier TL, Liang S, Vasdev N
08:20
Efficient Kit-like Radiosynthesis of Carbon-11 Labeled PET Tracers Using Solid Phase-supported Technique Boudjemeline M, Rochon PL, $*Kostikov A
08:40
11C-Carbonylation and Spirocyclic Iodonium Ylides for 18F-Fluorination Power Radiotracer Discovery *Rotstein BH
09:00
Incorporation of Fluorine into an OBOC Peptide Library by Copper-free Click Chemistry for the Discovery of PET Imaging Probes. *Murrell E, $Luyt L
09:20
Rapid Fluorine-18 Labeling of Polymer Nanoparticles for In Vivo Cancer Imaging *Berke S, Bailey J, Kampmann L, Glowacki B, Wuest M, Wuest F, Jurkschat K, Weberskirch R, $Schirrmacher R
09:40
Development, Evaluation and Radiosynthesis of 18F-labelled GW2580 Derivatives as a Potential Trk and CSF-1R PET Probe *Choi S, Bernard-Gauthier V, $Schirrmacher R
10:00
 
Coffee Break
10:20
Novel Radiofluorination Methods for PET Imaging *Liang SH
11:00
Silicon/Fluorine-18/PSMA: A Winning Team for PET Imaging of Prostate Cancer *Bailey JJ, Wuest M, Bouvet V, Bergman C, Janzen N, Genady A, Valliant J, Schirrmacher R, Wuest F
11:20
Organotrifluoborate Probes for Cancer Imaging: Observation of a Dramatic Uptake with a New Prosthetic for Prostate Cancer Imaging Lepage ML, $*Perrin DM, Bénard F, Lin K-S, Kuo H-T
11:40
Substrates Bearing Lysosomotropic Reporter Groups for PET Imaging Cathepsin Activity Vigliarolo BG, Chowdhury MA, Wang S, Moya IA, $Phenix CP
12:00
 
End of Session
BM4
201E
Bio-inorganic Chemistry - joint with IN
Organizer(s) - Bernie Kraatz, Deborah Zamble
Chair(s) - Deborah Zamble
08:00
Study the Interactions of Biometals with Microtubule Binding Domain of tau Protein, Contribution to Alzheimer's Diseases Ahmadi S, Zhu S, Dutta Majumdar R, Soong R, Sharma R, Wilson D, Simpson A, *Kraatz HB
08:20
Understanding the Role of Heavy Toxic Metals on Single Human Bladder Cancer Cells Li MSM, Filice FP, $*Ding Z
08:40
Chloride-accelerated CuO Nanoparticle-based Fenton Chemistry for Biofilm Removal $*Zhang X, Wang L
09:00
Dirhodium(II) Paddlewheel Complexes as Photodynamic Therapy Agents Song E, $Dunbar KR
09:20
Elaborating the "pa" and "ox" Ligand Families for Radiopharmaceutical Applications $*Orvig C
10:00
 
Coffee Break
10:20
Targeting Small-molecules to Treat Alzheimer's Disease $*Storr T, Gomes LMF, Jones MR
10:40
Aerobic Reaction of Dirhodium(II) Tetracarboxylate with Cysteine and its Derivatives $*Jalilehvand F, Enriquez Garcia A
11:00
Anticancer and Catalytic Activities of Redox-active Cu(II) Complexes of N,N and N,O Donor Ligands $*Walsby CJ, Prosser KE, Stott LA, Chu AW, Warren JJ
11:20
 
Rio Tinto Alcan Award Lecture
11:20
Ferrocene Peptides. Self-assembly and Materials Kraatz HB
12:00
 
End of Session
Tuesday PM
BM2
201C
Proteins
Organizer(s) - Jumi Shin, Drew Woolley
Chair(s) - Drew Woolley
13:40
Folding and Unfolding Dynamics of a Slipknotted Protein Probed by Single Molecule Force Spectroscopy He C, $*Li H
14:20
Engineering Protein Energy Landscapes Using Multistate Computational Protein Design $*Chica RA
15:00
Manipulating Cell Surface Glycans: Carbohydrate Processing Enzymes as Targets and Tools $*Kwan DH
15:20
Development and Mechanistic Characterization of a Novel HER3 Antibody Turowec JP, Lau E, Brown KR, *Moffat J, $Sidhu SS
15:40
 
Coffee Break
16:00
DAHP Hydrazone, a nM Inhibitor of DAHP Synthase that Controls Unbound Subunits' Conformations Heimhalt M, Zheng J, Wild J, Lin F, Balachandran N, $*Berti PJ
16:20
Random Mutagenesis of Cytochrome P450cam (CYP101A1) and New Reactions Catalyzed by the Mutants, with 3-Chloroindole and Endosulfan $*Plettner E, Kammoonah S, Balaraman P, Rehman A, Prasad B, Schwaneberg U
16:40
Enzymatic Synthesis of para-Hydroxycinnamic Acid Methyl Ester Using Rhodotorula glutinis Yeast Phenylalanine/Tyrosine Ammonia Lyase, and Its Potential Antibacterial Activity $*D'Cunha GB
17:00
Minimalist Protein ME47 Targets the Myc/Max:E-box DNA Network and Decreases Tumor Xenograft Growth $*Shin JA
17:40
 
End of Session
BM3
104A
Chemical Biology and Imaging - joint with OR
Organizer(s) - Peter Brown, Len Luyt, Mark Nitz, Chris Phenix, Santha Santhakumar
Chair(s) - Chris Phenix, Len Luyt
13:40
Radiometal Chelates: The Tail Wagging the Dog in Receptor-targeted Bioconjugates for PET Imaging $*Anderson CJ
14:20
Synthesis and Evaluation of a Bimodal 99mTc/Re Labelled T140 Analogue for Determining CXCR4 Expression in Prostate Cancer *Turnbull WL, $Luyt LG
14:40
89Zr Production via the 89Y(p,n)89Zr Reaction Using Pressed Target Alnahwi AH, *Tremblay S, $Guerin B
15:00
DFO-2: High Denticity DFO-based Chelator for 89Zr Radiochemistry Khozeimeh Sarbisheh E, Salih AK, Maghami M, Lewis JS, $*Price EW
15:20
A Novel 64Cu/NOTA-labeled Peptide with High Metabolic-resistance and NPY-Y1R Affinity Paquette M, Ait-Mohand S, Dumulon-Perreault V, Bénard F, *Guérin B
15:40
 
Coffee Break
16:00
Synthesis and Evaluation of a Series of Diphenyl Carbamates as Possible Cholinesterase Diagnostic Radioligands for Alzheimer's Disease $Darvesh S, Soley J, Ingram LR, Morris AM, Macdonald IR, Kelly SJ, McConnell M, Martin E, Pottie IR
16:20
One-step 18F-labeling of Dual-mode Fluorescent PET Tracers and Small Molecule PET Probes of Targets in Cancer and Neurology $*Perrin DM, Benard F, Lin K-S, Roxin A, Liu Z, Zhang C, Lau J, Zhang Z
16:40
Design and Synthesis of Stapled Ghrelin(1-20) Analogues Targeting GHSR-1a for Use in Cancer Diagnostics Lalonde TL, Shaw GS, Shepherd TGS, $*Luyt LGL
17:00
Unveiling Hidden Treasures in Biobanked Clinical Material. MS Histochemistry for Top-down Biomarfker Discovery on Formalin Fixed Paraffin Embedded Tissue $*Verhaert PDEM, Porta T, Verhaert MABJ, Heeren R, Ramael M
17:20
Teaching an Old Dog New Trick: Detection of Biologically Relevant Aldehydes by CEST MRI *Suchy M, Dang T, Lazurko C, $Shuhendler AJ
17:40
 
End of Session
BMP
Hall C
Poster Session
From 17:40 until 19:30
17:40
Novel Proposed Anticancer Platinum(IV) Complexes: Theoretical and Experimental Evaluation *Abedi A, Zare-Dehnavi M, Aghmasheh S
17:40
Synthesis, Docking Studies and Biological Evaluation of Triazole-thiazolidinedione/Rhodanine Hybrids Targeting Cyclooxygenase-2, 5-Lipoxygenase and Peroxisome Proliferator-activated Receptor $*Belal A, Elzahhar P, Ismail A, El-Yazbi A, Nassra R, Ibrahim T
17:40
Blocking Geranylgeranylation of Rap 1A in the Treatment of Hematological Cancers Lacbay CM, Vincent F, Ta V, Do L, Waller DD, Huang X-F, Sebag M, $*Tsantrizos YS
17:40
Searching for Natural Inhibitors of Cholinesterases by Hyphenated Chromatographic Techniques with High Resolution Mass Spectrometry and Bioautography $*Mroczek T
17:40
A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation *Wurz RP, Mohl D, Dellamaggiore K, Dou H, Javier N, Lo M-C, Sastri C, Lipford JR, $Cee V, McCarter JD
17:40
Bilayer Defects Facilitate DPPC Flip-Flop *Marquardt D, Heberle FA, Miti T, Katsaras J, Pabst G
17:40
Bioisosteric Replacement in Multitarget Inhibitor of HIV-1 p24 and Reverse Transcriptase Remtulla R
17:40
Reverse-enteric Iron Microencapsulation with Blend of Chitosan and Maltodextrin Using Spray Drying for Tea Fortification Siddiqui J, $Diosady LL
17:40
The Complexations of Biological Buffers by Cucurbit[7]uril and p-Sulfonated Calix[4,6]arenes $*Macartney DH, Selinger A
17:40
Development of Targeted Metallocene-based Bioactive Agents Harrypersad S, $Walsby CJ
17:40
Thermodynamic Characterization of Biometal Ions Binding to Tau Peptides Sharma R, Ahmadi S, $*Kraatz H-B
17:40
Biorthogonal Coupling of bis-Hemoglobin Tetramers by Metal Free Strain-promoted Alkyne Azide Cycloaddition Dubinsky I, *Singh S, $Kluger R
17:40
Using CRANAD-3 to Diagnose Early Alzheimer's Disease Pathology with Spectral Microscopy Jones MR, Joseph J, $Stys P K, *Tsutsui S
17:40
Synthesis and Electrochemical Regeneration of NAD+ Biomimetics Falcone N, $Kraatz H-B, *She Z
17:40
Hydrophobic Engineering of a Bacterial Nanodimensional Capsule Protein Ben Krayem O, *Gyamfi H, $Honek JF
17:40
Impact of Retinol Alcohol Group in Binding to Retinol Binding Protein 4 Remtulla R, *Shah N
17:40
Synthesis and Evaluation of Recently Isolated Immunologically Active Glycolipids Sadraei S, Igbokwe E, $*Trant JF
17:40
Direct Visualization of Drug-attenuated Hypoxia in PANC-1 Xenografts Bassan J, Edgar LJ, Vellanki RN, Wouters BG, *Nitz M
17:40
In-silico Studies of Callistemon viminalis Derived Natural Compounds $*Ahmad K, Athar F
17:40
Fluorescent Protein Labelling Using Small Molecular Fluorogenic FlARe Probes Tsao K, Chen Y, Acton S, $Keillor J
17:40
The Development of PgaB and IcaB Inhibitors, De-N-Acetylases Important for Biofilm Formation Morrison Z, $Nitz M
17:40
New Dimensions in Mass Cytometry: Cellular Barcoding with Tellurium Mass Tags *Park H, Willis L, Watson M, $Nitz M
17:40
Investigations on Ligand Binding to the Lipocalin Nitrophorin 4 Alamodi N, Daub E, $*Honek J
17:40
Design, Synthesis and Antibacterial Properties of Heterodimeric Polymyxin B3-Tobramycin Hybrids Domalaon R, Yang X, Zhanel GG, $*Schweizer F
17:40
Positive Feedback Events as Drivers of Ferroptotic Cell Death $*Bertrand RL
17:40
The Synthesis of Keratan Sulfate Glycosaminoglycans by a Glycosynthase Approach Zhang X, Bailleul G, Soowamber M, *Kwan D
17:40
Characterization of Site-directed Variants of Active-site Residues F55 and Y338 of Escherichia coli Cystathionine-beta Lyase Klein DA, $Aitken SM
17:40
Chemical Probes for PRMTs: Discovery, Validation and Application in Biology Szewczyk MM, Eram M, Luciani G, Freitas R, Brown PJ, Santhakumar V, Schapira M, Minden M, Jin J, Vedadi M, Arrowsmith CH, Barsyte-Lovejoy D
17:40
Characterization of a Unique Bifunctional Ornithine Decarboxylase/Arginase Mothersole RG, $Wolthers KR
17:40
Exploration of Active-site Residues in Escherichia coli Cystathionine Beta-lyase by Site Directed Mutagenesis Orzechowska J, Leclair AM, $*Aitken SM
17:40
Formation of Cytochrome c Complex with Cardiolipin at a Model Mitochondrial Membrane Surface Thong A, $*Tsoukanova V
17:40
Investigation of the Active Site of Cystathionine Gamma-synthase by Site-saturation Mutagenesis Belleperche M, $Aitken SM
17:40
Synthesis, Characterization and Optical Properties of Novel Merocyanine Dye Derivatives: Potential for Application in Aptamer Based Detection of Protein Targets Armstrong-Price D, $Manderville R
17:40
Investigation of Cytochrome P450 3A4 Cooperativity via Bioconjugation of Natural Ligands Ducharme JD, *Polic VP, $Auclair KA
17:40
Identification of Small Molecule Antagonists of HDAC6 Zinc-finger Domain Ubiquitin Interaction Harding RJ, Ferreira de Freitas R, Ravichandran M, Schapira M, Arrowsmith CM, $*Santhakumar V
17:40
H6eppy: A Chelating Ligand for Lanthanide and Actinide Based Radiopharmaceuticals Kostelnik TI, *Ramogida CF, $Orvig C
17:40
Evaluation of Chemical Diversity in Wild-growing Maritimes Hops Gallant ST, $*McCallum JL, Kirby CW, Wagner B
17:40
Immobilization of Biocatalysts in SBA-15 Ordered Mesoporous Silica with Cross-linked Enzyme Aggregates Crowley E, $*Vreugdenhil AJ
17:40
Rational Design of Altered Peptide Ligands for Treatment of Celiac Disease Meister D, Taimoory SM, $*Trant JF
17:40
Solid Phase Peptide Synthesis on a Polyamine-b-cyclodextrin Scaffold Vurgun N, $*Nitz M
17:40
Development of Blood Brain Penetrable IDO Inhibitors Goodwin-Tindall J, Kelly BJ, Diez-Cecilia E, Pan L, Sweeting B, Stover K, Stafford P, Brant MG, Wohnig S, Barden C, $*Weaver DF
17:40
The Next Generation of Ultrafast Electron Diffraction for Atomically Resolved Dynamics Feng JK, *Daoud H, $Miller RJD
17:40
Anticancerous and Antibacterial Properties of Alkyl-biguanides Hébert A, Rowell MC, Ferbeyre G, $*Schmitzer AR, Toulouse J, Pelletier J
17:40
Engineering M13-based Constructs for Use as Nanoscale Scaffolds Urquhart TU, Daub E, $*Honek JF
17:40
Microchip Real-time PCR Analyzer and Microchips with Lyophilized Reagents for Pathogen Detection *Slyadnev M, Gill S
17:40
Strained Alkyne Conjugation of Azido-BF2-Azadipyrromethenes McKay SJ, *Wu D, $O'Shea DF
17:40
'Unlocking Nature's Catalysts through the Power of Biology' - Elucidating the Biosynthesis of Nucleocidin a Fluorinated Natural Product Produced by Streptomyces calvus Pinkett K, $Zechel DL
17:40
Synthesis and Activity of Enantiopure Alicyclic Ethers on the Chemosensory Organ of the Ectoparasite of Honey Bees, Varroa Destructor Pinnelli G, $*Plettner E, Kumar NS, Soroker V
17:40
Development of Novel Scaffolds for Reversible Inhibitors of Tissue Transglutaminase Apperley KYP, Brunet-Filion N, $*Keillor JW
17:40
The Development of New Polymyxins: Synthesis and Antibacterial Properties of Di-homolipid Polymyxins Tays Q, Domalaon R, Zhanel GG, $*Schweizer F
17:40
Radiofluorination of Aptamers via Cysteine-cyanoquinoline Click Reaction *Suchy M, Hadizad T, Truong Y, Tayyabi E, $Shuhendler AJ
17:40
Deciphering Coiled Protein Interaction *Shrestha BR, Liberelle B, Crescenzo G, Banquy X
17:40
Teaching an Old Dog Another New Trick: A Minimalist Methyl 5-Methoxyanthranilate-based Fluorophores for the Identification of Biologically Relevant Carbonyl Compounds in Body Fluids *Suchy M, Lazurko C, $Shuhendler AJ
17:40
Stabilizing Colloidal Drug Aggregates Donders EN, Ganesh AN, Shoichet BK, $Shoichet MS
17:40
A Reactive Metabolite Found Its Lobster: The Monogamy between Cysteine and N-acetyl-p-benzoquinone Imine amongst Endogenous Protein Nucleophiles *Tayyabi E, $Shuhendler AJ
17:40
New Testosterone Dimers: Synthesis and Potential Applications Ouellette V, Vesper A-R, Descôteaux C, Tajmir-Riahi H-A, $*Bérubé G
17:40
Molecular Dynamics Study of the Substrate Specificity of Nucleoside Hydrolases Lenz SP, $*Wetmore SD
17:40
Quantifying a-MSH Peptides in Mouse Pituitary Using MALDI-FTICR Imaging West BJ, Grey AC, Mountjoy KG, Partridge A, Easterling ML, Derrick PJ
17:40
A Quantum Mechanical Study of the b- and d-Elimination Reactions Catalyzed by Bifunctional DNA Repair Enzymes in Humans and Bacteria Sowlati Hashjin S, *Wetmore S
17:40
Novel Antibiotics: Treatment of Multidrug-resistant Bacteria with Selective Pyruvate Kinase Inhibitors Hsieh THH, Kumar NS, Mandel AL, Tan J, Shidmoossavee FS, Heller M, Yurist-Doutsch S, Wee K, Campbell S, Reiner NE, Young RN, Dullaghan EM, *Jaquith JB
17:40
Monitoring the Structural Change of a-Synuclein Using Circular Dichroism Spectroscopy in the Presence of Metal Ions and Small Molecules Li SH, $Kerman K
17:40
Structure-activity Relationship of N-Cinnamoylanthranilates as TRPA1 Modulators *Chandrabalan A, Boa AN, Morice AH, $Sadofsky LR
17:40
Development of PET Radiotracers for in vivo Imaging of Proneurotrophin Receptors p75NTR and Sortilin Rochon PL, Boudjemeline M, $*Kostikov A
17:40
Bioinorganic Ligands Designed to Chelate Cu(I) and Disrupt Radical Formation in Alzheimer's Disease *Opare SKA, $Rauk A
17:40
Effects of Nickel and Cobalt on Biomimetic Lipid Membranes Umbsaar JE, Mundle RL, $*Prenner EJ
17:40
Dynamic Combinatorial Chemistry for Targeting Methyl Reader Proteins Warmerdam Z, Milosevich N, Gignac M, $Hof F
17:40
Small Molecule-based Activatable Photosensitizers Singh K, $*Beharry AA
17:40
Increasing the Brightness of Red Fluorescent Proteins Using Rational Design Nguyen E, Pandelieva AT, Damry AM, Chica RA
17:40
Investigation of Peptides Exhibiting Affinity Towards Advanced Materials Kim HSD, *Urquhart T, Monahan T, $Honek J
17:40
Investigation of the Catalysis and Inhibition of myo-Inositol Phosphate Synthase Ramos-Figueroa JS, $Palmer DRJ
17:40
Optimization and Structure Activity Relationships of a New Class of Pyruvate Kinase Inhibitors as Novel Antibiotics for the Treatment of Multidrug-resistant Bacteria Kumar NS, Hsieh THH, Mandel AL, Tan J, Shidmoossavee FS, Heller M, Yurist-Doutsch S, Wee K, Campbell S, Dullaghan EM, *Jaquith JB, Reiner NE, Young RN
17:40
Analysis of the Interaction between the Cocaine-binding Aptamer and its Ligands Using Fluorescence Spectroscopy *Shoara AA, $Johnson PE
17:40
Salt-controlled Two-site Binding of the Cocaine-binding Aptamer Slavkovic S, Neves MAD, Reinstein O, $*Johnson PEJ
17:40
Rapid Characterization of Folding and Binding Interactions with Thermolabile Ligands by DSC *Harkness RW, Slavkovic S, Johnson PE, $Mittermaier AK
17:40
Tobramycin-hybrid Antibiotics Overcome Resistance in MDR and XDR Pseudomonas aeruginosa via Membrane Perturbation and PMF Dissipation Idowu T, Zhanel GG, $*Schweizer F
17:40
Direct Fluorescence Monitoring of Inhibitor Binding to Dihydrodipicolinate Synthase from Campylobacter jejuni Majdi Yazdi M, Annadi K, $*Palmer DRJ
17:40
Analysis of Natural Products Produced by Extremophiles Isolated from Soda Lakes $Zechel DL, Pasternak ARO
17:40
Total Synthesis of Paenibacterin A1, a Broad Spectrum Cyclic Lipopeptide Antibiotic Noden M, $*Taylor SD
17:40
Assessing the Biological Effects of Two Natural Product Alkaloids and their Synthetic Intermediates Filip R, Shaw T, Nishida A, Pezacki JP
17:40
Determination of the Mechanism of Action of Armeniaspirole: A Gram-positive Antibiotic Labana P, $*Boddy CN, Dornan MH, Lafreniere M, Pezacki JP, Czarny TL, Brown ED
17:40
Mechanistic Investigation of OXA b-lactamase Inhibition by Avibactam Using 13C-NMR Spectroscopy Lohans CT, Brem J, Wang DY, Cahill ST, Claridge TDW, *Schofield CJ
17:40
Design, Synthesis and Evaluation of Direct FOXM1 Suppressors: Emergence of a Neglected Binding Force Tabatabaei Dakhili SA, $Perez Gomez, Velázquez C
17:40
Structure Based Design and Investigation of Benzimidazole Scaffolds as Potential Therapeutic Leads $*Yoganathan S, Barasa L
17:40
Integration of a Photoswitchable Moiety into siRNA Constructs as a Selective Control for Activity Hammill M, *Isaacs-Trepanier C, $Desaulniers J-P
17:40
A Computational Study of Genoprotection by Natural Products Found in Phyllanthus Orbicularis K Extract *Monteserín Castanedo LA, $Lamar AS, Matta CF
17:40
Impact of Low Power Microwave Irradiation on Biological Systems at Constant Bulk Temperature Mazinani SA, Stuart J, *Yan T
17:40
Low-cost Production of Small Intestine-targeted Drug Delivery Systems Sun CS, Homayun BH, $*Choi HJC, Montemagno CM
17:40
Thrombin Detection Using a Novel, Internally Modified Aptamer-based Biosensor Gray MD, *Deore PS, $Manderville RA
17:40
New Steroidal 17b-HSD10 Inhibitors against Alzheimer's Disease: D-ring Modifications, Selective Activity, and Metabolic Stability Boutin S, *Poirier D, Maltais R, Roy J
17:40
Investigation of NSAIDs and Fenamic Acid Derivatives as Potential Agents against Alzheimer's Disease MacMillan JWS, Meek AR, $*Weaver DF
17:40
Design and Synthesis of New Steroid Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors Dutour R, *Poirier D, Cortés-Benítez F, Roy J
17:40
The Molecular Basis of Amyloid Beta Remodelling from Toxic to Non-toxic Oligomers by EGCG in Alzheimer's Disease Ahmed R, VanSchouwen B, Ni X, Ortega J, $*Melacini G
17:40
Polylactide-based Dual-location Dual Stimuli-responsive Triblock Copolymer and its Nanoassemblies Bawa KK, $Oh J
17:40
Design and Synthesis of Highly Fluorogenic BODIPY-dimaleimide Reagents for in Vivo Protein Labeling Acton SL, Chen Y, Tsao K, $Keillor JW
17:40
Development and Biological Characterization of Synthetic anti-Frizzled Antibodies as Cancer Therapeutics Pavlovic Z, Adams J, Steinhart Z, Angers S, Moffat J, $Sidhu S
17:40
Does the Thermodynamic Stability of Canonical Nucleosides over Non-canonical Nucleosides a Possible Driver in Early Evolution? *Monteserín Castanedo LA, $Matta CF
17:40
A Convienent Late-stage Fluorination of Heterocyclic C-H Bonds Meanwell M, Nodwell M, Martin R, $*Britton R
17:40
Kinetic Analysis of Acetone Monooxygenases Supports Coenzyme Rotation at the Active Site during Catalysis Fordwour OB, $Wolthers KR
17:40
Secondary Metabolites and Biological Activity of the Algae Caulerpa racemosa Martinez L, $*D'Armas H, Segnini M, Brito L, Barrios J, D'Armas M
17:40
Mechanism Studies of Cyclic Lipodepsipeptide Antibiotics Using 19F-NMR Kralt BJ, Palmer M, $*Taylor SD
17:40
Manganese Porphyrin Dimer as an Optimized Redox Responsive MRI Contrast Agent Tieu H, *Lyu H-X, $Zhang X-A
17:40
The Contrasting Natures of the Enzyme-bound and Enzyme-free Breslow Intermediate: Carbanion vs Enamine Bielecki M, *Kluger R
17:40
Chemical Profiling of Canadian Medical Cannabis Yang Y, *Lewis MM, Wasilewski E, $Kotra LP
17:40
Towards the Determination of Inhibitor Specificity via the Development of a "Clickable" Probe against Tissue Transglutaminase Reed JA, $Keillor JW
17:40
The Use of Unnatural Amino Acids for the Design of p19 FRET Sensor Proteins Ahmed N, *Danielson D, $Pezacki JP
17:40
The Development of New Bioconjugation Methods for Studying Cytochrome P450 Enzymes Therien JPD, Cheong KJ, Scalabrini M, $Auclair K
17:40
Steps Towards Identification of Milk-clotting Enzymes Extracted from a Strain of Penicillium Heddar L, $Ismail AA, *Turnbull JL
17:40
Thioesterase Biocatalyzed Trimerization/Cyclization: Access to the Cereulides Heberlig GW, $*Boddy CN
17:40
Quantitative Target-mediated Inhibition of RCA Bialy RM, Li Y, $*Brennan JD
17:40
Structure-activity Relationship Study of a Fluorescent Chemosensor for Proximally Phosphorylated Proteins Cabral AD, *Kraskouskaya D, $Gunning PT
17:40
Atomic Force Microscopy of Glycogen Yu K, *Sullivan M, Minassian B, $Goh MC
17:40
Substrate Specificity of Carbohydrate Esterase 4 Enzymes PgaB and IcaB- both Partially de-N-acetylated b-1,6-linked Glucosamine (PNAG) Acting Enzymes that Are Required for Biofilm Formation Mendez Campos JE, Ariyakumaran R, $Nitz M
17:40
Computational Investigation of the Role of Bridging Water Molecules in GNRA Oligonucleotide Tetraloop Motifs Archambault P, Muchall HM, $*Peslherbe GH
17:40
Engineering Super Competitive Phosphotyrosine Binding Domains *Martyn GD, Veggiani G, $Sidhu S
17:40
Photo-control of the Antitumor Activity Using New E/Z Molecular Switches Martínez-López D, Piñeiro-Hermida S, López IP, García-Iriepa C, Alfaro-Arnedo E, Campos PJ, García-Pichel J, Sampedro D
17:40
Synthetic CD200/CD200R Antagonists as Potential Cancer Immunotherapy Zaman MM, Sidhu S
17:40
Chelators for Labeling Antibody Fragments with 99mTc(CO)3+ Core: Synthesis, Characterization and Initial In Vivo Evaluation $*Solomon VR, Zuluaga CG, Barreto K, Geyer CR, Fonge H
17:40
Defining the Role of Integrin aVb5 in Synapse Elimination through Targeted Chemical Probes Kapras V, Slattery W, $Menard F
17:40
Bioorthogonal Approaches for Labelling, Imaging and Capture of Living Pathogenic Bacteria Sherratt AR, Strmiskova M, $*Pezacki JP
17:40
Stimuli-responsive Bonds Sensitive towards Oxidative Stress Zare F, Potenza A, Leroux J, $*Gauthier MA
17:40
Understanding the Biological Activity of Vitamin E: Syntheis and Reactivity of Tocopherol and Tocotrienol Quinones Krueger N, Atkinson J
17:40
GPCR Activation by Small Molecule Ligands Pichugin D, Ye L, Huang K, $Prosser SR
17:40
The Effect of Glassy Film Topography and Surface Chemistry on Macrophage Function Luu H, Makaremi S, Levin D, Boyle J, Bowdish DME, Moran-Mirabal JM
17:40
Cage-like Proteins as Bioink Components for 3D Bioprinting $*Honek JF, Delgado AD, Nguyen LNM
17:40
Medicinal Chemistry of Medicinal Cannabis Lewis MM, Wasilewski E, $*Kotra LP
17:40
Molecular Basis of Dysregulation Caused by Disease-related Mutations of Protein Kinase A Swanson PL, Tu A, $*Melacini G
17:40
Conformational Studies on 2',4'-Modified Nucleoside Analogues and their Impact on Gene Silencing Oligonucleotides Malek-Adamian E, *Martinez-Montero S, Burai-Patrascu M, Fakhoury J, Moitessier N, $Damha MJ
17:40
Novel Isoxazole Derivatives Targeting Immune Thrombocytopenia Garrick R, Burke-Murphy E, *Branch D, $Kotra L
17:40
Making Synthetic Antagonists for the IL23 Signal Transduction Pathway Wellappili D, $Sachdev SS
17:40
Bioactive Compounds Isolated of Medical Plants Used to Functional Food $*Echavarria AP, D`Armas H, Matute NL
17:40
Computational Insights into the Catalytic Mechanism of GatA: An MD and QM/MM study Meister P, $Gauld JW
17:40
Clustering of CD22 Receptors on B Cells Using Synthetic Glycoconjugates Tran H, Daskhan G, Motyka B, West L, $*Cairo C
17:40
In Vitro Selection of DNAzyme Probes Activated by Legionella pneumophila Gopinathbirla S, *Gu J, $Li Y
17:40
Optimization and Application of Slow-Proton-Exchange (SPE) NMR pH Sensor Correa R, Perruchoud L, $Zhang X-A
17:40
Comparison of the Temperature Dependent Imino Exchange Rates for the Free and Ligand-bound Cocaine-Binding Aptamer Churcher Z, Hunter H, Neves M, $Johnson P
17:40
Understanding the Interaction of Gelatin/Pluronic/DNA System with Model Membrane: Langmuir Monolayer Study *Madkhali OA, $Wettig SD
17:40
Synthesis and Evaluation of Methylphosphonate Inhibitors of GlcNAc de-N-acetylases Associated with Bacterial Pathogenesis DiFrancesco BD, $Nitz M
17:40
Influence of Nucleotide Modifications on the Parallel-stranded Adenosine Duplex Copp W, Denisov A, Xie J, Liczner C, Noronha A, Safaee N, Gehring K, $*Wilds C
17:40
Investigating NOS-CaM Binding Interactions Using Surface Plasmon Resonance Lape JE, $Guillemette JG
17:40
A Highly Sensitive Fluorogenic Tocopherol Analogue for Monitoring the Antioxidant Status of Live Cells Greene LE, Lincoln R, $*Cosa G
17:40
Characterization of microRNA Cluster Role in the Regulation of Innate Immunity Ahmed N, *Singaravelu R, Quan C, $Pezacki JP
17:40
Dissecting the Molecular Basis of Nrf2-p21 Interaction Karunatilleke NC, Brickenden A, $*Choy W-Y
17:40
The Design and Development of a Fluorogenic Substrate for Live Cell Imaging of Glucocerebrosidase Activity Deen M, Gros C, Cecioni S, Xiaoyang S, Shen D, Bennet J, $Vocadlo D
17:40
Fluorophore Labeled Peptides for Improved Diagnostics of Crystal Arthropathies Lee J, Perez JB, MacCallum JL, $Derksen DJ
17:40
Development of Small Molecule PET Tracers Targeting GHS-R1a for the Imaging of Prostate Cancer Hou J, Kovacs M, $*Luyt L
17:40
Investigation of a Putative Lanthipeptide and Halogenase from Pseudoalteromonas flavipulchra Paudel YP, $*Ross AC
17:40
Discovery of D-Arginine Mimetics as Inhibitors of Protein Arginine Deiminases (PADs) *Koebel A, Wasilewski E, $Kotra LP
17:40
In Vivo Total Biosynthesis of Complex, Bacterial Sialic Acid Analogs Using Genetically Engineered Escherichia coli Hassan MI, Lundgren BR, Chaumun M, $*Boddy CN, Clark B, Whitfield D, Schoenhofen IC
17:40
An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products Daniel-Ivad M, Hameed N, Tan S, Dhanjal R, Socko D, Pak P, Gverzdys T, Elliot MA, $*Nodwell JR
17:40
Deciphering the Reactivity of Hydrazone Probes with the Human Proteome Shaw TA, Powdrill MH, Özcelik D, Sherratt AR, $Pezacki JP, *Beauchemin AM
17:40
Subdomain IB is a Thermodynamically Favourable but Kinetically Unfavourable Drug Binding Site of Human Serum Albumin (HSA) Liu H, Cheng W, $Zhang X-A
17:40
Synthesis and Preliminary Evaluation of Novel 12,13-dihydroandrographolide Analogues as Neuroprotective Agents $*Sagineedu SR, Tan K, Sakirolla R, Pichika MR, Hamzah AS, Shaari K, Stanslas J
17:40
The Synthesis of Analogues of Quinioline and Isoquinoline Based RNA G-quadruplex Stabilizers Othen ET, McRae EKS, McKenna SA, $*Sorensen JL
17:40
In Vitro Detection of Dopamine, and In Vivo Attenuation of Dopamine Related Behavior by a Dopamine Binding Aptamer McConnell EM, Callahan J, Ventura K, Holahan MR, $*DeRosa MC
17:40
Design, Synthesis and Evaluation of Novel Irreversible Inhibitors of Extracellular hTG2 Albert MR, McNeil NMR, $Keillor JW
17:40
Release Profiles from Silxoane-containing Phospholipid Liposomes Tongkoua Nkamou AP, $*Zelisko PM
17:40
Modulating the Amphiphilicity of Ice Recrystallization Inhibitors to Improve Red Blood Cell Recovery Poisson JS, Turner TR, Cottee ML, Acker JP, $*Ben RN
17:40
Biomineralization of Magnetotactic Bacteria Studied by Soft X-ray STXM and Ptychography Zhu X, $*Hitchcock AP, Bazylinski DA, Lins U, Tyliszczak T, Shapiro D
17:40
Metabolite Profiling of Multiple Buckwheat Varieties for Wireworm Control Nabuurs MH, McCallum JL, McKenzie DB, Noronha C, $*Kirby CW
17:40
Role of Tau Tubulin Kinases in Alzheimer's Disease Erdogan FE, *DeAraujo ED, $Gunning PG
17:40
Mass Cytometry Probes for Studying Sialic Acid Glycosylation Rana R, *Willis LM, $Nitz M
17:40
The Application of Oligonucleotide Templated Chemical Reactions to DNA Aptamer Based Sensor Platforms *Mattice CMC, Manthorpe JM, $DeRosa MC
17:40
Optical/Chemical Properties of Carbon Quantum Dots for Use as Biological Imaging Agents Geng X, Congdon TR, $Vetrone F, *Gauthier MA
17:40
Miconazole and Imazalil Analogues: Synthesis and Application as Agents that Inhibit Bacterial Biofilm Formation Tessier J, Golmohamadi M, Wilkinson KJ, $*Schmitzer AR
17:40
Chemical and Genetic Characterization of a Putative Siderophore Natural Product Produced by a Marine Bacterium *Timmermans ML, Chadwick E, Sharma S, $Ross AC
17:40
A Synthetic DNA Molecule with a Highly Stable Structure in Urea Zhang W, Liu M, Morrison B, Lee C, Salena BJ, $*Li Y
17:40
Gallium-68 DOTATATE Production with an Automated Synthesis System Phoenix S, Tremblay S, Ait-Mohand S, Ouellet R, Thibault P, Caouette L, Senta H, $*Guerin B
17:40
Synthesis of 2-Thiouracil PNA for Fmoc-based Synthesis of Pseudo-complementary Oligomers Martin-Chan T, *Hudson RHE
17:40
Syntheses of Novel Thiotetronate Antibiotic Compounds through Chemoenzymatic Oxidation and Amidation McKinnie SMK, Li J, $Moore BS
17:40
Targeting Methylated Peptides Using Highly Functionalized p-Sulfonato Calix[4]arenes as a Biomimic Shaurya A, $Hof F, Daze K, Garnett G, Starke M, Li J, Henderson T
17:40
Development of Oligosaccharide Substrates to Probe for PgaB/BpsB C-Terminal Activity Forman A, $Nitz M
17:40
Toward Solid-phase Peptide Fragment Ligation by a Traceless-Ugi Multicomponent Reaction Approach Vézina-Dawod S, Jobin S, Méjean A, Galindo SM, Liang X, $*Biron E
17:40
How oligo-DNA Interacts with Magnesium Aluminum Layered Double Hydroxide Nanoparticle: Mechanistic Implication to Gene Delivery $*Zhang X, Lu M, Andrea K
17:40
Identification and Development of Bio-protectants to Control Potato Storage Pathogens Vacon JND, Boyetchko SM, $*Kirby CW
17:40
Transition Metal Complexes as Possible Therapeutics for Alzheimer's Disease Gomes LMF, $Storr T, Walsby C, Gross Z, Silverman MA
17:40
Investigation of Isoform Specific Nitric Oxide Synthase Inhibitors Using Human Isozymes Estavillo DA, $Guillemette JG
17:40
The Preparation of Linkers for the Optimization of Small Molecule-drug Conjugates Brownsey DK, Papatzimas JW, Gorobets E, Maity R, Bahlis NJ, $Derksen DJ
17:40
Synthesis, Antimicrobial Activity and Structural Analysis of Pediocin PA-1 and its Analogs Bédard F, Hammami R, Zirah S, Rebuffat S, Fliss I, $Biron E
17:40
Novel, Irreversible Inhibitors of Human Tissue Transglutaminase: A Structure-activity Relationship Study McNeil NMR, Akbar A, Albert MR, Bourgeois K, Reed J, $Keillor JW
17:40
The Synthesis of Acylated Phloroglucinols as Novel Antibacterials Mittal N, Tatla H, $*Sorensen JL
17:40
Synthesis and Properties of Lumacaftor-based Molecular Probes Kanellis V, Junor P, $*Viirre RD
17:40
Addressing Allosteric Kinase Inhibition through Plasmodium falciparum Protein Kinase G Byun O, $Melacini G
17:40
DNAzyme Biosensors for Simplification of Foodborne Pathogen Detection Deng M, $Li Y, *Monsur A, Tram K, Sergio A
17:40
Photosensitized Radical Mediated Lipid Peroxidation in Single Giant Unilamellar Vesicles (GUVs) *Durantini AM, Bacellar I, Martínez SR, $Cosa G
17:40
A Tellurium-based Probe for Monitoring the Rates of Protein Synthesis Nguyen A, *Willis L, Bassan J, $Nitz M
17:40
Gold Nanoparticles as a Platform for Small Molecule SELEX *Smith M, $DeRosa MC
17:40
Design, Synthesis and Biological Evaluation of Small Molecule Agonists for the Type I Interferon Receptor using "Hot-spot" Mimetics Lewis MM, Sarswat A, Matarrazo A, Park J, Majchrzak-Kita B, Fish EN, $*Kotra LP
17:40
Sildenafil Treatment of Bronchopulmonary Dysplasia Associated Pulmonary Hypertension (BPD-PH) in a Rat Model Luong K, Wish J, Xing Y, $Yi A, Wong C
17:40
Development of a Probe to Elucidate the Role of N-Aryl Aldonamides in the Cryopreservation of Hematopoietic Stem and Progenitor Cells Adam MK, Charlton TA, Jahan S, Pineault N, $*Ben RN
17:40
Probing Drug Binding to NBD1 of SUR2A, the Regulatory Subunit in Cardiac KATP Channels Park M, *López-Alonso J, $Kanelis V
17:40
Nutritional Intervention Modulates Lactate to Pyruvate Ratios in Human Sweat during Exercise Guevara DR, Ngan SY, Layo A, Griffin B, Donald E, $Merante F
17:40
Modification at the Penam C6-position for the Inhibition of Carbapenem-hydrolyzing Class D b-lactamases (CHDLs) in Gram-negative Bacteria Pena D, $*Boudreau M
17:40
Synthesis of Small Molecule, Sulfated N-arylaldonamides for the Cryopreservation of Human Hematopoietic Stem and Progenitor Cells Charlton TA, Adam MK, Jahan S, Pineault N, $*Ben RN
17:40
Synthesis and Evaluation of [18F]EVT901 as a PET Radiotracer Candidate for In Vivo Imaging of p75 Neurotrophin Receptor Rochon PL, Boudjemeline M, $*Kostikov A
17:40
A Chimeric Nucleobase - Phenylazo Derivative as an Intrinsic Nucleobase Quencher Martin-Chan T, El Samman A, Park G, $*Hudson RHE
17:40
Novel Non-covalent Inhibitors of Protein Arginine Deiminases (PADs) as Potential Treatments for Multiple Sclerosis (MS) *Curiel Tejeda EJ, Bello AM, Wasilewski E, Koebel A, Dunn S, $Kotra LP
17:40
In Vitro Selection of Fluorogenic RNA-cleaving DNAzymes at High Basicity Zakaria S, *Zhu W, $Li Y
17:40
Evaluating the Role of Hydride Tunneling in Phosphite Dehydrogenase Catalysis Howe GW, *van der Donk WA
17:40
Development of Fibrinogen Aptamer-conjugates for MRI and CT applications Koudrina A, $*DeRosa MC
17:40
DNA Aptamer Toxin-binding Motif Revealed Using an Internal FRET Probe Van Riesen AJ, McNamee JT, Deore PS, $Manderville RA
17:40
Deciphering the Biosynthetic Logic of Exopolysaccharide Phosphonate Tailoring Rice K, Batul K, Bartlett C, Bansal S, Schaefer J, Cegelski L, Weadge J, $*Horsman G
17:40
Studying the Reactivity of CS2 with 1,4,5,6-tetrahydropyrimidine Alshamrani AK, *Jessop PG
17:40
Synthesis and Properties of Novel Cyanine Dyes and their Incorporation into Oligonucleotides for Aptasensor Development for Improved Protein Detection Deore PS, $*Manderville RA
17:40
Developing Colourimetric Biosensors for Prostate Cancer Biomarkers Manochehry S, $Li Y
17:40
Structure-activity Relationship of Benzimidazolium Salts as Anion Transmembrane Transporters Lecluse M, *Tessier J, Gravel J, $Schmitzer AR
17:40
Characterization of Protein Solutions Using SAXS *Quinn JE, $Bolze J, Beckers D
17:40
Ruthenium Complexes of Anastrozole as Multitargeting Chemotherapeutic Agents Golbaghi G, Haghdoost M, $*Castonguay A
17:40
A Modular Approach to the Synthesis of Drug-based Molecular Probes Junor P, $*Viirre RD
17:40
Engineering Exosomes for Targeted Anti-HCV Activity through Metabolic Inhibition Alonzi RC, *Powdrill MH, $Pezacki JP
17:40
Mapping the Interactions between Insulin and EGCG as a Potential Chemical Adjuvant in Type II Diabetes Treatment Lee J, Ahmed R, $*Melacini G
17:40
Multistate Approaches for Computational Protein Design Davey JA, Damry AM, Euler CK, Goto NK, Chica RA
17:40
Isolation of Ulcerprotectivec Cucurbitane Type Triterpenoids fro Cucumis Melo Seeds $*Bal G
Wednesday AM
BM3
104A
Chemical Biology and Imaging - joint with OR
Organizer(s) - Peter Brown, Len Luyt, Mark Nitz, Chris Phenix, Santha Santhakumar
Chair(s) - Mark Nitz
08:00
Targeted Strategies Mediating Immune Recognition Of Cancer Rullo AF, $Spiegel DA
08:20
Targeted Polarization of Immunomodulatory Macrophages through a Multivalent Display of Synthetic Glycans Edgar LJ, Elich MK, $Paulson JC
08:40
Exploiting Divergent Enzyme Selectivities for Green Chemistry and Narrow Spectrum Antimicrobials $*Horsman GP
09:00
Genomes to the Next Generation Antibiotics Magarvey NA
09:20
Transglutaminase-mediated Protein Labelling: Successes and Challenges Rachel N, $*Pelletier JN
09:40
Enzymology by Terahertz Chemical Microscopy Nahar S, Xavier R, Lopez Y, Doucet N, Kiwa T, Ozaki T, $*Gauthier MA
10:00
 
Coffee Break
10:20
DNA Recognition and Sensing with Designed Peptides and Metallopeptides Rodríguez J, Bouzada D, Gómez-González J, Barka G, Boga S, Pérez-Márquez LA, Mosquera J, Rama G, García-Peña D, Mascareñas JL, Vázquez López M, $*Vázquez ME
11:00
SERS-based Sensors of Oncogenic Transcription Factors Pazos E, Garcia-Algar M, Penas C, Torruella A, Pazos-Perez N, Guerrini L, Vázquez ME, Garcia-Rico E, Mascareñas JL, Alvarez-Puebla RA
11:20
 
End of Session
BM6
201B
Nucleic Acid Chemistry and Biology
Organizer(s) - Andrew Beharry
Chair(s) - Andrew Beharry
08:00
Studies on Modified dNTPs for Use in SELEX Experiments $*Perrin DM, Wang Y, Liu E, Lam CH, Renders M, Miller E
08:20
Photochemical Control of siRNAs $*Desaulniers JP, Hammill M, Hagen G
08:40
Targeted Genetic Therapeutic Delivery to Glioblastoma Stem Cells *Arnold AE, Malek-Adamian E, Le PU, Damha MJ, Petrecca K, $Shoichet MS
09:00
Expanded Functionality of Nucleic Acids via Nucleobase Modification $*Hudson RHE
09:20
Tuning DNA/RNA Sugar Conformation via Intramolecular H-F Interactions *O'Reilly D, Kurian J, Moitessier N, $Masad D
09:40
A Ca2+-specific RNA-cleaving DNAzyme $*Liu J
10:00
 
Coffee Break
10:20
DNA Quadruplexes as a Scaffold for Self Assembling Sensors $*Linkletter BA, Henley J, Price JTD
10:40
Modifying and Detecting RNA with Bioorthogonal Reactions $*Devaraj NK
11:20
 
End of Session
Wednesday PM
BM3
104A
Chemical Biology and Imaging - joint with OR
Organizer(s) - Peter Brown, Len Luyt, Mark Nitz, Chris Phenix, Santha Santhakumar
Chair(s) - Mark Nitz
13:40
 
Teva Canada Limited Biological and Medicinal Chemistry Lectureship Award Lecture
13:40
Interrogating Host-pathogen Interactions with Activity-based Probes $*Pezacki JP
14:20
Aldehyde & Seek: Chemical Methods for Sensing a Stressful Biomarker Shuhendler A
14:40
Far-red Photo-switches for Controlling Protein Structure and Function $*Woolley A
15:00
Chemical-proteomic Strategies to Investigate Reactive Cysteines $Weerapana E
15:40
 
Coffee Break
16:00
Genome-wide Chemical Mapping of O-GlcNAcylated Proteins in Drosophila melanogaster $*Vocadlo DJ, Liu T-W, Myschyshyn M, Sinclair DA, Cecioni S, Beja K, Honda BM, Morin RD
16:20
Functional Analysis of Carbohydrate-active Enzymes and Proteins: Novel Chemical Probes for Glycoside Hydrolases Jain N, $Brumer H
16:40
Feedback Inhibition of hGFAT1 Caused by O-GlcNAc Metabolic Chemical Reporters *Walter LA, Batt A, Darabedian N, $Pratt MR
17:00
Human Neuraminidase Cleavage of Unusual Sialic Acids $*Cairo CW, Hunter CD, Khanna N, Richards MR
17:20
b-Galactosidase Probes for Detection of Cellular Senescence by Mass Cytometry Willis LM, Lumba MA, Santra S, Schito L, Rey S, Wouters B, $Nitz M
17:40
 
End of Session
BM6
201B
Nucleic Acid Chemistry and Biology
Organizer(s) - Andrew Beharry
Chair(s) - Andrew Beharry
13:40
Engineering Molecular Devices Containing DNA Aptamers and DNAzymes $*Li Y, Liu M, Brennan JD
14:00
Target-molecule Triggered Release Technology *Tsae PK, Zhang X, $DeRosa MC
14:20
Salt-controlled Two-site Ligand Binding by the Cocaine-binding Aptamer $*Johnson PE, Slavkovic S, Neves MAD, Churcher ZA, Shoara AA
14:40
Riboswitching on the Light: Imaging Cyclic Dinucleotides Involved in Bacterial and Immune Signaling $*Hammond MC
15:20
Recognition of Guanine Quadruplexes by Small Molecule Ligands: Towards Anticancer Applications Miron CE, Mergny J-L, $*Petitjean A
15:40
 
Coffee Break
16:00
Applying the Chemist's Toolbox for Studying Nucleic Acid Structure and Function $*Damha MJ, Habibian M, Yahyaee-Anzahaee M
16:20
How Does the Conformation of Adducted DNA Depend on Lesion Structure? Kung RW, $Wetmore SD
16:40
Cyclic Azobenzene as a Photoswitch to Regulate DNA Hybridization Jun M, Dhruval J, Eljabu F, Yalagala Y, *Yan T
17:00
Simple Biosensors Based on Urease-mediated Litmus Test Chang D, Tram K, Liu M, Manochehry S, $*Li Y
17:20
Base Editing: Genome Editing Without Double-stranded DNA Cleavage Kim YB, Komor AC, Levy JM, Packer MS, Zhao KT, $*Liu DR
17:40
Introducing Turnover and Increasing Selectivity towards Single Nucleotide Polymorphisms in a Ligase Chain Reaction Using a Destabilizing Abasic Lesion $*Gibbs JM, Kausar A, Osman EA, Gadzikwa T, Hales S, Alladin-Mustan BS
18:00
 
End of Session
Thursday AM
BMG1
201E
General Session 1
Organizer(s) - Drew Woolley
Chair(s) - Andrew Woolley
08:00
Intramolecular Nitrone-akene Cycloaddition for Bioorthogonal Click Labelling Santos JT, $Nitz M
08:20
Fluorogenic BODIPY Dyes for Imaging Chemistry within Cellular Membranes Lincoln R, Greene LE, Zhang W, $*Cosa G
08:40
Free Energy Landscape Remodeling of the Cardiac Pacemaker Channel Explains the Molecular Basis of Familial Sinus Bradycardia Boulton S, Akimoto M, Akbarizadeh S, $*Melacini G
09:00
Bio-orthogonal Mediated Nucleic Acid Transfection of Cells via Cell Surface Engineering O'Brien PJ, $*Yousaf MN, Elahipanah S, Rogozhnikov D
09:20
Towards the Heterologous Expression of Lichen Biosynthetic Gene Clusters in Aspergillus Oryzae Bertrand RL, Abdel-Hameed M, Quan ZY, Awakawa T, Abe I, $*Sorensen JL
09:40
The Biological Outcomes Associated with DNA Adduct Formation: What Can Be Learned from Computer Modeling? $*Wetmore SD
10:00
 
Coffee Break
10:20
Development of a Fluorescent Calcium Indicator with a Novel Topology Aggarwal A, *Zarowny L, $Campbell R
10:40
Connecting the Dots between the Pathways in Bacterial Biofilm Formation: Quorum Sensing and Cyclic Nucleotide Second Messengers Bordeleau E, Betancourt F, Bell M, *Yan T
11:00
Structural Studies of Parallel-stranded Nucleic Acid Assemblies $*Gehring K
11:20
A Suite of Methods to Measure Enzyme Kinetics Using Isothermal Titration Calorimetry Di Trani J, $Mittermaier A
11:40
Mechanistic Studies on Lipopeptide Antibiotics *Taylor RM, $Taylor SD, Palmer M
12:00
 
End of Session
BMG2
201B
General Session 2
Organizer(s) - Drew Woolley
Chair(s) - Voula Kanelis
08:00
Structure-activity Relationships and Selectivity Studies of Peptidic Inhibitors for Epigenetic Reader Proteins Belonging to the Polycomb Family Milosevich N, Gignac M, Simhadri C, Anderson C, Horvath S, *Croft C, $Hof F
08:20
The Discovery and Evaluation of OICR-9429, a Small Molecule Antagonist of the WDR5-MLL Interaction Zepeda-Velázquez C, Getlik M, Smil D, Bolshan Y, Poda G, Senisterra G, Wu H, Allali-Hassani A, Wasney GA, Barsyte-Lovejoy D, Dombrovski L, Marcellus R, Li F, Schapira M, Brown P, Arrowsmith CH, Vedadi M, $*Al-awar R
08:40
Adjuvant Strategies for Restoring b-Lactam Activity against Antibiotic Resistant Bacteria $*Boudreau MA
09:00
Understanding the Carbohydrate Binding Specificity of Clostridium Difficile Toxins *Ling C-C, Zhang P, Sadowka J, Kitova E, Bundle DR, Klassen J, Ng KKS
09:20
Blocking Resistance to Cationic Antimicrobial Peptides in Pseudomonas aeruginosa $Miller Conrad LC
09:40
Successful Cryopreservation of Human Hematopoietic Stem and Progenitor Cells using Novel Ice Recrystallization Inhibitors Charlton T, Adam M, Jahan S, Pineault N, Acker JP, $*Ben RN
10:00
 
Coffee Break
10:20
Stimuli Responsive DNA Micelles for Controlled Small Molecule Release Prinzen AL, $Sleiman HF
10:40
Discovery of Potent and Selective Targeted Covalent Inhibitors of Human Tissue Transglutaminase Akbar A, McNeil NMR, Eckert RL, $*Keillor JW, Kerr C
11:00
A Tobramycin Vector Enhances Synergy and Efficacy of Efflux Pump Inhibitors against Multidrug-resistant Gram-negative Bacteria Yang X, Goswami S, Gorityala BK, Domalaon R, Lyu Y, Kumar A, Zhanel GG, $*Schweizer F
11:20
Development of a PROTAC Small Molecule Conjugate Toolset with Anti-cancer Applications Papatzimas JW, Gorobets E, Maity R, Bahlis NJ, $*Derksen DJ
11:40
Design and Synthesis of a Photo-labeling Analogue of Ivacaftor to Probe Its Putative Binding Ssite on Mutant CFTR Hamilton CM, $*Young RM, Bear CE, Viirre RD, Toutah K, Hung M, Qureshi Z
12:00
 
End of Session
Thursday PM
BMG1
201E
General Session 1
Organizer(s) - Drew Woolley
Chair(s) - Andrew Woolley
13:40
Exploiting Thermosensitive Diels-Alder Linkages for the Delivery of Ru(II)-arene Complexes to Cancer Cells Haghdoost M, Poulet S, Golbaghi G, $*Castonguay A
14:00
Bifunctional Ligand Design for the Restoration of Wild-type Function in Mutant p53 Miller JJ, Orvain C, Reviriot Y, Jozi S, Gaiddon C, Warren J, $*Storr T
14:20
Protein Engineering of Nanodimensional Multisubunit Proteins Gyamfi H, van der Ven A, Feng D, Urquhart T, Daub E, $*Honek JF
15:00
 
Coffee Break
15:20
Simulating Microbial Competition in the Laboratory as a Means to Accelerate Natural Products Discovery $*Sit CS
15:40
LC-MS Based Metabolomics for Natural Products Discovery $*Kerr RG
16:00
Construction and Array of a Soil Metagenomic Library to Access Natural Product Biodiversity *Gosse JT, Hill P, $Boddy C
16:20
Easy to Use Capillary Columns for Fast Analysis of Complex Samples. How Do We Make it a Reality? Morin S, Toole E
16:40
 
End of Session
BMG2
201B
General Session 2
Organizer(s) - Drew Woolley
Chair(s) - Voula Kanelis
14:00
Structural and Functional Analysis of Disease-causing Mutations in the Human Sulfonylurea Receptor Alvarez CP, Stagljar M, $*Kanelis V
14:20
Elucidating the Molecular Mechanisms by which the HNH Endonuclease gp74 Activates the Terminases in Bacteriophage HK97 Weiditch S, $Kanelis V, *Maxwell K
14:40
Revisiting a Bacterial Membrane Permeabilization Assay for Quantitative Evaluation of Membrane Disrupting Agents Gravel J, Paradis-Bleau C, $*Schmitzer AR
15:00
 
Coffee Break
15:20
Direct Observation of Two Component Peptide Fibril Assemblies through MALDI Imaging West BJ, *Medini K, Williams DE, Brimble MA, $Gerrard JA
15:40
Identification and Characterization of Bacillus subtilis Transglutaminase Peptide Substrates for Use in Bio-conjugation and Bio-catalytic Applications Oteng-Pabi SK, $Keillor J
16:00
Metal Coordination as a Strategy for Improving the Aqueous Solubility of Chemotherapeutics Prosser KE, Leung A, Lewis AR, Harrypersad S, *Walsby CJ, Bally M
16:20
Gadolinium-free Blood Pool MRI Contrast Agents for High Clinic Field (3T) Angiography Liu H, Sasidharan P, Constantinescu V, $Zhang X-A
16:40
 
End of Session